Expression of genes for Kisspeptin ( KISS1 ), Neurokinin B ( TAC3 ), Prodynorphin ( PDYN ), and gonadotropin inhibitory hormone ( RFRP ) across natural puberty in ewes
نویسندگان
چکیده
منابع مشابه
Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice.
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and identities of upstream neuropeptides that control and time puberty remain poorly understood. Indeed, how various reproductive neural gene systems change before and during puberty, and in relation to one another, is not well-characterized. We detailed the daily pubertal profile (from postnatal day [P...
متن کاملInactivating KISS1 mutation and hypogonadotropic hypogonadism.
Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release. Inactivating mutations in the genes encoding the human kisspeptin receptor (KISS1R, formerly called GPR54), neurokinin B (TAC3), and the neurokinin B receptor (TACR3) result in pubertal failure. H...
متن کاملNew developments in kisspeptin, neurokinin B and dynorphin A regulation of gonadotropin-releasing hormone pulsatile secretion.
corporating the mechanisms by which KNDy neuropeptides modulate the reproductive axis (see [1] and the cover of this issue). The second article, by Goodman et al. [2] , reviews the roles of kisspeptin, NKB and Dyn in GnRH pulse generation as gathered from a comprehensive series of excellent studies in sheep from their laboratory as well as from equally detailed and incisive experiments in goats...
متن کاملThe effects of supraphysiological levels of testosterone on neural networks upstream of gonadotropin-releasing hormone neurons
Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing hormone (GnRH) system in the hypothalamus of male rats. Also, we assessed the expression of two excitatory (kisspeptin and...
متن کاملRole of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates
In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neuroendocrine mechanism of puberty, we investigated the contribution of kisspeptin and NKB signaling to the pubertal increase in GnRH release using r...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2020
ISSN: 2051-817X,2051-817X
DOI: 10.14814/phy2.14399